文献类型：期刊文献

英文题名：Regioselective Difluoromethane sulfonylation and Triflylation of Resorufin Derivatives

作者：Tan, Qingwei[1];Zhao, Shuxuan[1];Li, Yuyao[1];Jiang, Jialing[1];Tang, Huiling[1];Chen, Yefeng[1];Peng, Yan[1];Xie, Hexin[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Pharm, State Key Lab Bioreactor Engn,Shanghai Key Lab Ne, Shanghai 200237, Peoples R China

年份：2021

卷号：23

期号：21

起止页码：8477

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000716793100070)】；

基金：We are thankful to the National Natural Science Foundation of China (22077031), the Research Program of State Key Laboratory of Bioreactor Engineering, and the Fundamental Research Funds for the Central Universities for financial support.

语种：英文

摘要：Reported herein is a regioselective difluoromethane sulfonylation or triflylation of resorufin derivatives, which allows easy access to 2-difluoromethane sulfonylated or triflylated resorufin derivatives in good yields. The installation of a difluoromethane sulfonyl group significantly increases the solubility of the chromophore and expands its Stokes shift. A difluoromethane sulfonylated resorufin-based fluorogenic probe proved to be able to image enzyme activity in live cells with a stronger fluorescence signal compared with its resorufin counterpart.