文献类型：期刊文献

英文题名：Cu2O-catalyzed cascade phosphinylation/cyclization of 2′-aminochalcones for the synthesis of hemi-indigo derivatives

作者：Liu, Xian[1,2];Hao, Liqiang[1,2];Wang, Yangyang[1,2];Yu, Xiao[1,2];Yang, Zhaoziyuan[1,2];Liu, Yiping[3];Ji, Yafei[1,2]

机构：[1]Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Chongqing Med & Pharmaceut Coll, Sch Pharm, Chongqing 401331, Peoples R China

年份：2024

卷号：22

期号：21

起止页码：4249

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20242016074352);WOS:【SCI-EXPANDED(收录号:WOS:001215828300001)，CCR-EXPANDED(收录号:WOS:001215828300001)】；

基金：We gratefully thank the National Natural Science Foundation of China (Project No. 21676088) for financial support.

语种：英文

外文关键词：Catalysts - Copper oxides

摘要：A Cu2O-catalyzed cascade phosphinylation/cyclization reaction of 2 '-aminochalcones and diphenylphosphine oxides to produce hemi-indigo derivatives has been developed. This strategy facilitates the sequential formation of a C-P bonds and a C-N bond in a single reaction step. Notably, the approach features one-pot operation, an earth-abundant copper catalyst, readily available starting materials, a broad substrate scope and high compatibility with functional groups, providing 33 compounds in acceptable yields.