文献类型：期刊文献

英文题名：Enantiocomplementary decarboxylative hydroxylation combining photocatalysis and whole-cell biocatalysis in a one-pot cascade process

作者：Xu, Jian[1];Arkin, Mamatjan[1];Peng, Yongzhen[1];Xu, Weihua[1];Yu, Huilei[2];Lin, Xianfu[1];Wu, Qi[1]

机构：[1]Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：21

期号：8

起止页码：1907

外文期刊名：GREEN CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000465398000005)，CCR-EXPANDED(收录号:WOS:000465398000005)】；

基金：The financial support from the National Natural Science Foundation of China (21574113, 21472169), the Zhejiang Provincial Natural Science Foundation (LY19B020014) and the Fundamental Research Funds for the Central Universities (2018QNA3010) is gratefully acknowledged. The authors thank Dr Meilan Huang and Dr Yangmei Li for their fruitful discussion.

语种：英文

摘要：Designing a green, highly efficient and stereoselective catalytic system to generate valuable enantioenriched products is a long-standing goal in green chemistry. Here, we report a one-pot cascade combining photocatalysts with (R)- or (S)-selective ketoreductases for the decarboxylative carbonylation of carboxylic acids and the subsequent bioreduction to generate valuable chiral alcohols. Using this approach, various chiral alcohols with complementary (R)- or (S)-configurations were prepared with good yields (up to 93%) and excellent stereoselectivity (up to 99% ee). Such a photochemo-enzymatic one-pot whole-cell process combines the advantages of both photocatalysts and enzyme catalysts and provides a mild, green, metal-free and highly stereoselective alternative in asymmetric decarboxylative hydroxylation reactions.