文献类型：期刊文献

英文题名：Chiral multifunctional thiourea-phosphine catalyzed asymmetric [3+2] annulation of Morita-Baylis-Hillman carbonates with maleimides

作者：Deng, Hong-Ping[1];Wang, De[2,3];Wei, Yin[1];Shi, Min[1,2,3]

机构：[1]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China;[2]E China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2012

卷号：8

起止页码：1098

外文期刊名：BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000306550300001)】；

基金：We thank the Shanghai Municipal Committee of Science and Technology (11JC1402600), National Basic Research Program of China (973)-2010CB833302, and the National Natural Science Foundation of China for financial support (21072206, 20472096, 20872162, 20672127, 21121062 and 20732008) and Mr. Jie Sun for performing X-ray diffraction.

语种：英文

外文关键词：asymmetric [3+2] annulation; maleimides; Morita-Baylis-Hillman carbonates; multifunctional thiourea-phosphine; organocatalysis

摘要：We have developed a multifunctional thiourea-phosphine catalyzed asymmetric [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with maleimides, which can efficiently construct functionalized cyclopentenes bearing three contiguous stereocenters in moderate to excellent yields and excellent diastereo- and enantioselectivities. A plausible mechanism has been also proposed on the basis of control experiments and previous literature.