文献类型：期刊文献

英文题名：Enantioselective synthesis of indolo[2,3-b]-dihydrothiopyranones via [3+3] cycloaddition of chiral α,β-unsaturated acylammonium salts

作者：Jin, Jing-Hai[1];Li, Xiang Yu[1];Luo, Xiaoyan[1];Deng, Wei-Ping[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2018

卷号：74

期号：47

起止页码：6804

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000450134700008)，CCR-EXPANDED(收录号:WOS:000450134700008)】；

基金：This work is supported by the Shanghai Committee of Science and Technology (no. 17ZR1407600); National Natural Science Foundation of China (No. 21372074).

语种：英文

外文关键词：alpha,beta-unsaturated acylammonium salts; [3+3] cycloaddition; indolo[2,3-b]-dihydrothiopyranones

摘要：A nucleophile-catalyzed Michael addition/proton transfer/lactonization (NCMPL) organocascade process of chiral alpha,beta-unsaturated acylammonium salts and indoline-2-thiones is described, which delivers the indolo[2,3-b]dihydrothiopyranone motifs in high yields (up to 97%) with good to excellent enantioselectivities (up to 98% ee). (C) 2018 Elsevier Ltd. All rights reserved.