文献类型：期刊文献

英文题名：Synthesis and Characterization of Antimicrobial Polyvinyl Pyrrolidone Hydrogel as Wound Dressing

作者：Zheng, A.[1];Xue, Y.[1,2];Wei, D.[1];Li, S.[1];Xiao, H.[2];Guan, Y.[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Univ New Brunswick, Dept Chem Engn, Fredericton, NB E3B 5A3, Canada

年份：2014

卷号：12

期号：3

起止页码：297

外文期刊名：SOFT MATERIALS

收录：;EI(收录号：20142617869768);WOS:【SCI-EXPANDED(收录号:WOS:000340128800001)】；

基金：This work was financially supported by the Shanghai Natural Science Foundation (No. 12ZR1407800), the Shanghai Leading Academic Discipline Project (B502), and the Shanghai Key Laboratory Project (08DZ2230500).

语种：英文

外文关键词：Antimicrobial activity; Guanidine oligomer; Hydrogels; Wound dressing

摘要：Novel antimicrobial PVP-GP hydrogels were prepared by polycondensation of hexamethylenediamine and guanidine hydrochloride, followed by cross-linking reaction using N-vinyl pyrrolidone (NVP) and N,N'-methylene bisacrylamide (MBAm). The products were characterized by H-1 NMR, FTIR, SEM, and their performances for wound dressing applications were also evaluated. Swelling study showed that the water absorptivity of the hydrogels decreased as the cross-linking density increased either in water or in physiological saline solution. Both PVP and PVP-GP hydrogels possessed excellent mechanical strength which could address the requirements for wound dressing. The water vapor transmission rates (WVTR) of PVP and PVP-GP hydrogels were in the range of 1727-2320 g/m(2)/day, indicating that the prepared hydrogels were suitable for wound dressings without dehydrating the wound surface or accumulating exudates. Kirby-Bauer inhibition zone test and microbe penetration assay proved that the PVP-GP hydrogels had high antimicrobial activity.