文献类型：期刊文献

英文题名：Preparation of pore expanded mesoporous hydroxyapatite via auxiliary solubilizing template method

作者：Zeng, Fanyan[3];Wang, Jing[3];Wu, Yi[3];Yu, Yuanman[3];Tang, Wei[3];Yin, Manli[3];Liu, Changsheng[1,2,3]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2014

卷号：441

起止页码：737

外文期刊名：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

收录：;EI(收录号：20134717009252);WOS:【SCI-EXPANDED(收录号:WOS:000329260800094)】；

基金：The authors are indebted to the financial support from the National Basic Research Program of China (973 Program, 2012CB933600), the National Natural Science Foundation of China (No. 31271011), the National Science and Technology Support Program (2012BAI17B02), and the Program for New Century Excellent Talents in University (NCET-12-0856).

语种：英文

外文关键词：Mesoporous materials; Hydroxyapatite; Soft-tempalte; Pore expanding agent; Micelles

摘要：Here we present a facile approach to prepare pore-expanding mesoporous hydroxyapatite (mesoHAp) using solubilized micelle template. 1,3,5-rimethy benzene (TMB) was selected as auxiliary solubilizer together with the general soft template cetyltrimethylammonium bromide (CTAB). Enlarged mesoporous can be obtained through the swelling of micelle. Numerous individual nano channels can be observed under TEM images spreading and penetrating within the mesoHAp nanorods. Compared to the mesoHAp without TMB, the channels have enlarged dimensions of about 5-15 nm and the space between the nano channels are filled with an ordered crystalline HAp structure with typical hexagonal crystals. A probable mechanism is that TMB can enter into the amphiphilic CTAB micelle to form swelled TMB/CTAB-PO(4)(3-)complex, and in the presence of Ca2+, Ca-9(PO4)(6) clusters are preferentially condensed on the micelle surface due to the conformation compatibility between the identical hexagonal shapes of the micelles and Ca-9(PO4)(6). Interesting, the pore size distribution of mesoHAp was centered at similar to 4.7 nm and 10 nm, which might be arisen from the coexistence of both unsolubilized CTAB micelles and solubilized TMB/CTAB micelles. The pore-enlarged mesoHAp nanoparticles presented a platform for protein delivery system and might be applicable in biocomposite scaffold for bone regeneration. (C) 2013 Elsevier B.V. All rights reserved.