文献类型：期刊文献

英文题名：Application of AIEgens in Temperature Detection

作者：Li, Xiangyu[1,2];Zhu, Zhirong[1,2];Lyu, Yanting[1,2];Zhang, Cuiyun[1,2];Hu, Shanshan[1,2];Wang, Qi[1,2];Zhu, Wei-Hong[1,2]

机构：[1]East China Univ Sci & Technol, Inst Fine Chem, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, Shanghai 200237, Peoples R China

年份：2024

卷号：6

期号：4

起止页码：1356

外文期刊名：ACS MATERIALS LETTERS

收录：;EI(收录号：20241115747884);WOS:【SCI-EXPANDED(收录号:WOS:001181891200001)】；

基金：This work was supported by the National Key Research and Development Program of China (2021YFA0910000), the NSFC Science Center Program (22222803, 21788102), the China Postdoctoral Science Foundation (2022M72142),and the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03).

语种：英文

外文关键词：Signal to noise ratio

摘要：Temperature is a pivotal factor governing the metabolic processes of biological organisms, and monitoring temperature at the cellular level with high spatial and temporal resolution holds significant importance for understanding physiological and pathological conditions. Conventional macroscopic thermometers are not suited for cellular-scale measurements, necessitating the development of microscopic molecular thermometers. Fluorescent molecular thermometers have received widespread attention due to their noninvasive nature and versatility in reporting various parameters. In particular, molecular thermometers with aggregation-induced emission (AIE) properties have gained prominence owing to their superior stability, excellent signal-to-noise ratio, high contrast, and adaptability. The luminescence of AIE fluorophores often relies on a restriction of intramolecular motion (RIM) mechanism; therefore, the fundamental premise underlying the design of AIE thermometers is the modulation of molecular motion through temperature variations. In this Review, we summarize recently reported AIE thermometers, focusing on their molecular design, temperature response mechanisms, and applications in cell imaging. Furthermore, an exploration of the structure-activity relationships governing these thermometers is undertaken with the aim of offering valuable design strategies for diverse AIE temperature sensors.