文献类型：期刊文献

英文题名：Antiaging Effects of Vicatia thibetica de Boiss Root Extract on Caenorhabditis elegans and Doxorubicin-Induced Premature Aging in Adult Mice

作者：Liu, Wenwen[1];Guan, Yunhui[2];Qiao, Sicong[1];Wang, Jiqun[1];Bao, Keting[1];Mao, Zhifan[1];Liao, Liang[1];Moskalev, Alexey[3];Jiang, Bei[4];Zhu, Jin[1];Xia, Conglong[2];Li, Jian[1,2,5];Hu, Zelan[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[2]Dali Univ, Coll Pharm & Chem, 5 Xue Ren Rd, Dali 671000, Yunnan, Peoples R China;[3]Russian Acad Sci, Komi Sci Ctr, Inst Biol, Lab Geroprotect & Radioprotect Technol,Ural Branc, 28 Kommunisticheskaya St, Syktyvkar 167982, Russia;[4]Dali Univ, Inst Mat Med, 5 Xue Ren Rd, Dali 671000, Yunnan, Peoples R China;[5]Tongji Univ, Shanghai Peoples Hosp 10, Clin Med Sci & Tech Innovat Ctr, Sch Med, Shanghai 200092, Peoples R China

年份：2021

卷号：2021

外文期刊名：OXIDATIVE MEDICINE AND CELLULAR LONGEVITY

收录：;EI(收录号：20213510829845);WOS:【SCI-EXPANDED(收录号:WOS:000687546500005)】；

基金：We would like to thank ManuscriptEdit (https://www.manuscriptedit.com) for English language editing (ORDER10471). We thank the Caenorhabditis Genetic Center (CGC) for providing the worm strains. The financial support for this research was provided by the National Natural Science Foundation of China (22037002 and 81872747), the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (TP2018025), the Innovation Program of Shanghai Municipal Education Commission, the Innovative Research Team of High-level Local Universities in Shanghai, and the Chinese Special Fund for State Key Laboratory of Bioreactor Engineering (2060204).

语种：英文

外文关键词：Antioxidants - Free radicals - Plants (botany) - Heat resistance - Mammals

摘要：The roots of Vicatia thibetica de Boiss are a kind of Chinese herb with homology of medicine and food. This is the first report showing the property of the extract of Vicatia thibetica de Boiss roots (HLB01) to extend the lifespan as well as promote the healthy parameters in Caenorhabditis elegans (C. elegans). For doxorubicin- (Doxo-) induced premature aging in adult mice, HLB01 counteracted the senescence-associated biomarkers, including P21 and gamma H2AX. Interestingly, HLB01 promoted the expression of collagen in C. elegans and mammalian cell systemically, which might be one of the essential factors to exert the antiaging effects. In addition, HLB01 was also found as a scavenger of free radicals, thereby performing the antioxidant ability. Lifespan extension by HLB01 was also dependent on DAF-16 and HSF-1 via oxidative stress resistance and heat stress resistance. Taken together, overall data suggested that HLB01 could extend the lifespan and healthspan of C. elegans and resist Doxo-induced senescence in mice via promoting the expression of collagen, antioxidant potential, and stress resistance.