文献类型：期刊文献

英文题名：Diselenide-containing poly(epsilon-caprolactone)-based thermo-responsive hydrogels with oxidation and reduction-triggered degradation

作者：Zhang, Yan[1];Xu, Ying[1];Wei, Chao[1];Zhang, Yuanying[1];Yang, Liu[1];Song, Zhongchen[2];Lang, Meidong[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Stomatol, Dept Periodontol,Peoples Hosp 9, Shanghai 200011, Peoples R China

年份：2017

卷号：4

起止页码：172

外文期刊名：MATERIALS TODAY CHEMISTRY

收录：WOS:【ESCI(收录号:WOS:000424195700018)】；

基金：Financial support from the National Natural Science Foundation of China (21274039), Shanghai Pujiang Program (14PJD014), Shanghai Natural Science Foundation (17ZR1407100), 111 Project (B14018), Specialized Research Fund for the Doctoral Program of Higher Education (20130074110007) and National Key Research and Development Program (2016YFC1100700) are gratefully acknowledged.

语种：英文

外文关键词：Hydrogels; Diselenide; Poly(epsilon-caprolactone); Degradation; Oxidation and reduction

摘要：Herein, novel multi-responsive injectable polyester hydrogels were reported based on the diselenide-containing poly(epsilon-caprolactone) copolymers ((mPEG-PCL-Se)(2)). The (mPEG-PCL-Se)(2) solution remained a free-flowing state at ambient temperature but spontaneously turned into a semisolid hydrogel upon heating to physiologic temperature. The phase transition temperature was examined to be dependent on the composition and aqueous concentration of the copolymers. More importantly, the thermo-responsive hydrogels were endowed with oxidation and reduction-triggered degradation by the incorporation of diselenide groups. Accordingly, the degradation of poly(epsilon-caprolactone)-based hydrogels was greatly improved and the rate of degradation was well regulated by the concentration of hydrogen peroxide (H2O2) or glutathione (GSH). This superior stimuli-responsive degradation could lead to an enhanced drug release of encapsulated drug (Doxorubicin, DOX). Thus the oxidation and reduction-triggered degradable diselenide-containing poly(epsilon-caprolactone) hydrogels would offer great potential for the controlled drug delivery. (C) 2017 Published by Elsevier Ltd.