文献类型：期刊文献

英文题名：Universal and One-Step Modification to Render Diverse Materials Bioactivation

作者：Chen, Qi[1,2];Zhang, Xinyue[2];Zhang, Donghui[1];Liu, Guojian[2];Ma, Ke[2];Liu, Jingjing[2];Ma, Kaiqian[2];Chen, Minzhang[2];Li, Yongsheng[2];Liu, Runhui[1,2,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sci Ctr Materiobiol & Dynam Chem, Ctr Biomed Mat, Sch Mat Sci & Engn,Minist Educ, Shanghai 200237, Peoples R China;[3]Soochow Univ, Stateand Local Joint Engn Lab Novel Funct Polymer, Suzhou 215123, Peoples R China

年份：2023

卷号：145

期号：32

起止页码：18084

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20233314561932);WOS:【SCI-EXPANDED(收录号:WOS:001041089200001)】；

基金：This research was supported by the National Natural Science Foundation of China (21774031, 22205063), Program of Shanghai Academic/Technology Research Leader (20XD1421400), the fellowship of China Postdoctoral Science Foundation (2021M701189), Shanghai Sailing Program (No. 22YF1410100), Open Research Fund of State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials (Soochow University, Suzhou, 215123, China), and Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences).

语种：英文

外文关键词：Adhesives - Amino acids - Molecules - Peptides - Tissue regeneration

摘要：Bioactive materials that can support cell adhesion andtissue regenerationare greatly in demand in clinical applications. Surface modificationwith bioactive molecules is an efficient strategy to convert conventionalbioinert materials into bioactive materials. However, there is anurgent need to find a universal and one-step modification strategyto realize the above transformation for bioactivation. In this work,we report a universal and one-step modification strategy to easilymodify and render diverse materials bioactivation by dipping materialsinto the solution of dibutylamine-DOPA-lysine-DOPA (DbaYKY) tripeptide-terminated cell-adhesivemolecules, & beta;-peptide polymer, or RGD peptide for only 5 min.This strategy provides materials with a stable surface modificationlayer and does not cause an undesired surface color change like thewidely used polydopamine coating. This one-step strategy can endowmaterial surfaces with cell adhesion properties without concerns onnonspecific conjugation of proteins and macromolecules. This universaland one-step surface bioactivation strategy implies a wide range ofapplications in implantable biomaterials.