文献类型：期刊文献

英文题名：Enhancing the Efficacy of Photodynamic Therapy through a Porphyrin/POSS Alternating Copolymer

作者：Jin, Jiangui[1];Zhu, Yucheng[1];Zhang, Zhenghe[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Minist Educ, Shanghai Key Lab Funct Mat Chem, Key Lab Specially Funct Polymer Mat & Related Tec, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：57

期号：50

起止页码：16354

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20184606074132);WOS:【SCI-EXPANDED(收录号:WOS:000453346300016)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 21574039 and 21875063). We are indebted to Prof. Axel H.E. Muller (Gutenberg-Universitat Mainz, Germany) for discussion regarding to self-assembly of block copolymers.

语种：英文

外文关键词：block copolymer; photodynamic therapy; porphyrin; POSS; self-assembly

摘要：Aggregation-induced quenching (AIQ) of photosensitizers greatly reduces the quantum yield of singlet oxygen generation and mitigates the efficacy of photodynamic therapy (PDT). We have prepared an alternating copolymer starting from 4-vinylbenzyl-terminated tetraphenylporphyrin (VBTPP) and maleimide isobutyl polyhedral oligomeric silsesquioxane (MIPOSS), via alternating reversible addition-fragmentation chain transfer (RAFT) polymerization. Porphyrin and POSS are installed on the amphiphilic block copolymers backbone in an alternating fashion and POSS completely inhibits the aggregation of porphyrin units via stacking. The amphiphilic block copolymer can self-assemble into nanoparticles and its application in PDT treatment was tested. These porphyrin-containing polymeric nanoparticles display high photochemical yield and phototoxicity in vitro and in vivo, providing a novel strategy to enhance the PDT efficacy.