文献类型：期刊文献

英文题名：Acetylation of N-heteroaryl bromides via PdCl₂/(o-tolyl)₃P catalyzed Heck reactions

作者：He, Tianxiong[1];Tao, Xiaochun[1];Wu, Xinyan[1];Cai, Lisheng[2];Pike, Victor W.[2]

机构：[1]E China Univ Sci & Technol, Organomet Chem Lab, Shanghai 200237, Peoples R China;[2]NIMH, Mol Imaging Branch, NIH, Bethesda, MD 20892 USA

年份：2008

期号：6

起止页码：887

外文期刊名：SYNTHESIS-STUTTGART

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000254841000008)，CCR-EXPANDED(收录号:WOS:000254841000008)】；

语种：英文

外文关键词：acetylation; butyl vinyl ether; isopropanol; N-heteroaryl bromides

摘要：A new user-friendly and convenient method for the acetylation of N-heteroaryl bromides is described. This process is based on the palladium-catalyzed olefination of an N-heteroaryl bromide with butyl vinyl ether, followed by acid hydrolysis of the intermediate heteroaryl vinyl ether in situ. Isopropanol at 85 degrees C, in the presence of K3PO4 center dot 3H(2)O (2 equiv), PdCl2 (2 mol%) and (o-tolyl)(3)P (4 mol%), provided the best conditions, giving yields of N-heteroaryl bromides up to 75%.