文献类型：期刊文献

中文题名：Novel nanoparticles composed of chitosan and β-cyclodextrin derivatives as potential insoluble drug carrier

英文题名：Novel nanoparticles composed of chitosan and β-cyclodextrin derivatives as potential insoluble drug carrier

作者：Yan-Zuo Chen[1,2,3];Yu-Kun Huang[1,2];Yuan Chen[2,4];Ya-Jing Ye[1,2];Kai-Yan Lou[2];Feng Gao[1,2,3]

机构：[1]Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology;[2]Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology;[3]Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology;[4]Shanghai Institute of Health Sciences

年份：2015

卷号：26

期号：7

起止页码：909

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2015_2016】；PubMed;

基金：financially supported by Postdoctoral Science Foundation of China (No. 2014M550222);Shanghai Postdoctoral Sustentation Fund (No. 14R21410500);the support from School of Pharmacy, Fudan University & the Open Project Program of Key Lab of Smart Drug Delivery (Fudan University), Ministry of Education (No. SDD2014-2);State Key Laboratory of Molecular Engineering of Polymers (Fudan University, No. K2015-15);the Fundamental Research Funds for the Central Universities (Nos. 22A201514055 and WY1213013 ECUST)

语种：英文

中文关键词：Chitosan Cyclodextrin derivatives Ionic gelation method Drug delivery system

外文关键词：Chitosan Cyclodextrin derivatives Ionic gelation method Drug delivery system

摘要：This research was aim to develop novel cyclodextrin/chitosan （CD/CS） nanocarriers for insoluble drug delivery through the mild ionic gelation method previously developed by our lab. A series of different β- cyclodextrin （β-CD） derivatives were incorporated into CS nanoparticles including hydroxypropyl-β- cyclodextrin （HP-β-CD）, sulphobutylether-β-cyclodextrin （SB-β-CD）, and 2,6-di-O-methy-βcyclodex- trin （DM-β-CD）. Various process parameters for nanoparticle preparation and their effects on physicochemical properties of CD/CS nanoparticles were investigated, such as the type of CD derivatives, CD and CS concentrations, the mass ratio of CS to TPP （CS/TRP）, and pH values. In the optimal condition, CDICS nanoparticles were obtained in the size range of 215-276 nm and with the zeta potential from 30.22 mV to 35.79 mY. Moreover, the stability study showed that the incorporation of CD rendered the CD/CS nanocarriers more stable than CS nanoparticles in PBS buffer at pH 6.8. For their easy preparation and adjustable parameters in nanoparticle formation as well as the diversified hydrophobic core of CD derivatives, the novel CD/CS nanoparticles developed herein might represent an interesting and versatile drug delivery platform for a variety of poorly water-soluble drugs with different physicochemical properties.
This research was aim to develop novel cyclodextrin/chitosan （CD/CS） nanocarriers for insoluble drug delivery through the mild ionic gelation method previously developed by our lab. A series of different β- cyclodextrin （β-CD） derivatives were incorporated into CS nanoparticles including hydroxypropyl-β- cyclodextrin （HP-β-CD）, sulphobutylether-β-cyclodextrin （SB-β-CD）, and 2,6-di-O-methy-βcyclodex- trin （DM-β-CD）. Various process parameters for nanoparticle preparation and their effects on physicochemical properties of CD/CS nanoparticles were investigated, such as the type of CD derivatives, CD and CS concentrations, the mass ratio of CS to TPP （CS/TRP）, and pH values. In the optimal condition, CDICS nanoparticles were obtained in the size range of 215-276 nm and with the zeta potential from 30.22 mV to 35.79 mY. Moreover, the stability study showed that the incorporation of CD rendered the CD/CS nanocarriers more stable than CS nanoparticles in PBS buffer at pH 6.8. For their easy preparation and adjustable parameters in nanoparticle formation as well as the diversified hydrophobic core of CD derivatives, the novel CD/CS nanoparticles developed herein might represent an interesting and versatile drug delivery platform for a variety of poorly water-soluble drugs with different physicochemical properties.