文献类型：期刊文献

中文题名：介孔钙硅酸盐改性硫酸钙骨水泥的体内降解及成骨性能

英文题名：In vivo degradability and osteogenesis of m-CS/CSC bone cement

作者：许晨辉[1];何阿祥[1];谢栋[1];陈洁[2];魏杰[2];杨立利[1]

机构：[1]第二军医大学附属长征医院脊柱三科,上海200003;[2]华东理工大学材料科学与工程学院,200237

年份：2016

卷号：24

期号：6

起止页码：544

中文期刊名：中国矫形外科杂志

外文期刊名：Orthopedic Journal of China

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：国家自然科学基金资助项目(编号:81572194);国家自然科学基金资助项目(编号:81371383);上海市曙光计划项目(编号:13SG38)

语种：中文

中文关键词：介孔硅酸钙;硫酸钙;复合骨水泥;降解性;成骨性

外文关键词：mesoporous calcium silicate, calcium sulfate, composite bone cement, degradability, osteogenesis

摘要：[目的]通过动物体内置入实验评价介孔硅酸钙改性硫酸钙骨水泥(m CSC)在体内的降解性和成骨性能。[方法]将m CSC和对照样硫酸钙(CSC)骨水泥置入新西兰大白兔右侧股骨末端骨缺损,于术后4、8、12周取样,通过组织学和免疫组化分析骨水泥在体内的降解性和成骨性能。[结果]m CSC复合骨水泥置入兔股骨缺损部位12周后修复骨缺损,组织病理学和免疫组化分析表明:伴随着m CSC材料的降解,大量新生骨组织生成,成骨量显著高于CSC;且VEGF和Ⅰ型胶原染色阳性表达率明显高于CSC。[结论]m CSC具有优良的生物相容性、降解性和成骨性能,能促进新骨再生,是一种潜在的骨修复材料。
[ Objective]To investigate the in vivo degradability and osteogenesis of the m- CS/CSC（ m -CSC） cements in animal model [ Method] Eighteen New Zealand rabbit were divided into experiment group and the control group, with 9 in each. In the experiment group, the m - CSC cements were implanted into the bone defects of femur bone, and the in vivo de- gradability and osteogenesis of the cements was investigated by histological detect arid immunohistochemical staining after im- plantation for 4, 8 and 12 weeks. CSC cement was implanted into the same bone defect in another group as a control. [ Result] The bone defects were repaired after m - CSC cements had been implanted for 12 weeks. The results of histological elevation and immunohistochemical staining from animal model revealed that massive bony tissue formed and at the same time, the cement obviously degraded, indicating that the osteogenesis of the m - CSC were better than CSC, and the positive express ratio of VEGF and COLL I of the m -CSC were also better than that of CSC. [ Conclusion] m -CSC has good biocompatibility, degrad- ability and osteogenesis potential, which could promote bone regeneration.