文献类型：期刊文献

英文题名：Near-infrared light switching nitric oxide nanogenerator with "linkage mechanism" for tumor targeting multimodal synergistic therapy

作者：Zhang, Wei[1];Xuan, Qize[1];Zhang, Qi[1];Wang, Tong[1];Wang, Chen[2];Li, Hui[2];Chen, Chao[1,2];Wang, Ping[3]

机构：[1]East China Univ Sci & Technol, Biomed Nanotechnol Ctr, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Univ, Inst Environm Pollut & Hlth, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China;[3]Univ Minnesota, Dept Bioprod & Biosyst Engn, St Paul, MN 55108 USA

年份：2023

卷号：66

期号：2

起止页码：586

外文期刊名：SCIENCE CHINA-CHEMISTRY

收录：;EI(收录号：20225213302711);WOS:【SCI-EXPANDED(收录号:WOS:000903432500001)】；

基金：This work was supported by the National Natural Science Foundation of China (21908059), the China Postdoctoral Science Foundation (2019M651419), the Shanghai Sailing Program (19YF1410900, 21YF1451700), the Natural Science Foundation of Shanghai (22ZR1415400), the Fundamental Research Funds for the Central Universities (22221818014), the Shanghai Post-doctoral Excellence Program (2018011), the Foundation of State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences (GZKF202031) and the Open Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：英文

外文关键词：NO generator; NIR-trigger NO release; linkage mechanism; gas therapy; targeted synergistic therapy

摘要：Gaseous therapy based on nitric oxide (NO), as a potential anti-tumor treatment strategy, has attracted great attention, but the targeted and controlled gas release in the tumor site still remains a challenge. In addressing these difficulties, a near-infrared (NIR) light-triggered NO release nanogenerator with a "linkage mechanism " was designed on the basis of sodium nitroprusside-doped mesoporous Prussian blue nanoparticles, in which the outer structure was modified with pH-sensitive gatekeeper chitosan and tumor-targeting agent folic acid. The "linkage mechanism " can achieve precise release of NO under the control of photothermal effect at tumor site, which can couple photothermal therapy and gas therapy to address the premature release of gas during transportation. Meanwhile, the amount of released gas can be controlled by adjusting the irradiation time and laser intensity. Furthermore, as-fabricated nanocomposites hold high photothermal conversion efficiency under NIR laser irradiation, resulting in the on-demand release of NO and chemotherapy drugs. The released NO can inhibit the expression of hypoxia-inducible factor alpha (HIF-1 alpha) and alleviate the hypoxic tumor microenvironment, thereby enhancing the efficacy of chemotherapy. Moreover, in vitro and in vivo experiments exhibited remarkable antitumor efficiency, and the synergistic gas/chemo/photothermal therapy of deep tumors was achieved. These findings indicate an effective strategy to stimulate further the development of deep tumor therapy, which may provide new insights into other NO-related medical applications.