文献类型：期刊文献

英文题名：Diverse interactions between AIEgens and biomolecules/organisms: Advancing from strategic design to precision theranostics

作者：Ding, Qihang[1,2];Xu, Xiaoyu[2];Li, Yang[3,4];Li, Baoping[2];Saiding, Qimanguli[5,6];Gu, Meijia[2];Tao, Wei[5,6];Tang, Ben Zhong[7];Kim, Jong Seung[1]

机构：[1]Korea Univ, Dept Chem, Seoul 02841, South Korea;[2]Wuhan Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Peoples R China;[3]East China Univ Sci & Technol, Inst Fine Chem, Key Lab Adv Mat, Frontiers Sci Ctr Materiobiol & Dynam Chem,Sch Che, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Shanghai 200237, Peoples R China;[5]Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA;[6]Harvard Med Sch, Dept Anesthesiol, Boston, MA 02115 USA;[7]Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Shenzhen CUHK, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China

年份：2024

卷号：10

期号：7

起止页码：2031

外文期刊名：CHEM

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001267548700001)】；

基金：ACKNOWLEDGMENTS This work was financially supported by the National Research Foundation of Korea (2018R1A3B1052702) , the National Natural Science Foundation of China (22307036) , and the China Postdoctoral Science Foundation (2023M731079) .

语种：英文

摘要：Fluorophores play a pivotal role in the contemporary biomedical field due to their versatile interaction with a diverse range of biomolecules and organisms. They are revolutionizing methodologies aimed at studying biological processes and biomolecules that perform specific functions within organisms. Regrettably, a significant proportion of traditional fluorophores are susceptible to aggregation-induced quenching (ACQ). This phenomenon results in reduced labeling efficiency and increased vulnerability to photo- bleaching in target analytes, significantly limiting their potential for broader biomedical applications. By contrast, aggregation- induced emission (AIE) provides a unique molecular framework for facilitating the interaction between AIE luminogens (AIEgens) and biomolecules/organisms both in vivo and in vitro. . Thus, a comprehensive summary of the interaction between the AIEgens and biomolecules/organisms for detection, imaging, and targeted therapeutic applications promises coverage of an emergent and expansive research domain with the potential to replace conventional disease diagnosis and treatment modalities.