文献类型：期刊文献

英文题名：Injectable Self-Healing and Anti-Dissolving Low-Molecular-Weight Hydrogels Enabled by Ionic Cross-Linking for Cell Encapsulation

作者：Zhang, Jiahao[2]; Jin, Kaiyu[2]; Feng, Yifei[2]; Lu, Da[2]; Chen, Mai[2]; Wang, Hucheng[2]; Jin, Cheng[1]; Wang, Dengyu[1]; Li, Zhiling[1]; Wang, Yiming[2,3]

机构：[1] Department of Pharmacy, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; [2] School of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, China; [3] Shanghai Key Laboratory for Intelligent Sensing and Detection Technology, East China University of Science and Technology, Shanghai, 200237, China

年份：2025

卷号：14

期号：1

起止页码：20

外文期刊名：ACS Macro Letters

收录：EI(收录号：20245217571362)

语种：英文

外文关键词：Biocompatibility - Cells - Encapsulation - Hydrogels - Microgels - Scaffolds - Scaffolds (biology) - Self-healing materials

摘要：Injectable behavior is often observed in polymer-based hydrogels yet is rarely achieved in low-molecular-weight hydrogels (LMWHs), the realization of which may boost the development of new soft materials for biomedical applications. Here, we report on injectable self-healing and antidissolving LMWHs that are formed through a simple ionic cross-linking strategy, showing a fundamental application for the encapsulation of living cells. The LMWHs are formed by simply mixing Ca2+ with negatively charged supramolecular polymers. Surprisingly, the resultant hydrogels are capable of rapidly self-healing within seconds after damage, showing an unexpected injectable function. When the hydrogel is injected into an aqueous medium, continuous macroscopic hydrogel fibers can be produced. Interestingly, the hydrogel can remain intact in the aqueous medium, showing impressive antidissolving behavior which is less observed in other LMWHs. Furthermore, the hydrogel is demonstrated to be nontoxic and can be used as a cytocompatible scaffold for living cells. This work may open an avenue toward injectable and antidissolving LMWHs for the ever-expanding list of applications in biotherapy and bioprinting. ? 2024 American Chemical Society.