文献类型：期刊文献

英文题名：Metabolic engineering and synthetic biology strategies for producing high-value natural pigments in Microalgae

作者：Cao, Kai[1,2];Cui, Yulin[1];Sun, Fengjie[3];Zhang, Hao[1];Fan, Jianhua[4];Ge, Baosheng[5,6];Cao, Yujiao[7];Wang, Xiaodong[1];Zhu, Xiangyu[1,2];Wei, Zuoxi[2];Yao, Qingshou[1];Ma, Jinju[1];Wang, Yu[1];Meng, Chunxiao[1];Gao, Zhengquan[1]

机构：[1]Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China;[2]Shandong Univ Technol, Sch Life Sci & Med, Zibo 255049, Peoples R China;[3]Georgia Gwinnett Coll, Sch Sci & Technol, Dept Biol Sci, Lawrenceville, GA 30043 USA;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[5]China Univ Petr East China, State Key Lab Heavy Oil Proc, Qingdao 266580, Peoples R China;[6]China Univ Petr East China, Ctr Bioengn & Biotechnol, Qingdao 266580, Peoples R China;[7]Shandong Univ Technol, Sch Foreign Languages, Zibo 255090, Peoples R China

年份：2023

卷号：68

外文期刊名：BIOTECHNOLOGY ADVANCES

收录：;EI(收录号：20233514636850);WOS:【SCI-EXPANDED(收录号:WOS:001118499900001)】；

基金：This work was supported by the National Natural Science Foundation of China (31972815, 42176124) , the Natural Science Foundation of Shandong Province (ZR2020ZD23, ZR2019ZD17, ZR2021QD137, ZR2021MC051 and ZR2021MC134) , the scientific research fund of Binzhou Medical University (BY2021KYQD18, BY2021KYQD25, and BY2021KYQD28) , and the Yantai Economic-Technological Develop-ment Area Innovation Pilot Project (2021RC007) .

语种：英文

外文关键词：Microalgal pigments; Synthetic pathways; Metabolic modification; Synthetic biology; Omics technology

摘要：Microalgae are microorganisms capable of producing bioactive compounds using photosynthesis. Microalgae contain a variety of high value-added natural pigments such as carotenoids, phycobilins, and chlorophylls. These pigments play an important role in many areas such as food, pharmaceuticals, and cosmetics. Natural pigments have a health value that is unmatched by synthetic pigments. However, the current commercial production of natural pigments from microalgae is not able to meet the growing market demand. The use of metabolic engineering and synthetic biological strategies to improve the production performance of microalgal cell factories is essential to promote the large-scale production of high-value pigments from microalgae. This paper reviews the health and economic values, the applications, and the synthesis pathways of microalgal pigments. Overall, this review aims to highlight the latest research progress in metabolic engineering and synthetic biology in constructing engineered strains of microalgae with high-value pigments and the application of CRISPR technology and multi-omics in this context. Finally, we conclude with a discussion on the bottlenecks and challenges of microalgal pigment production and their future development prospects.