文献类型：期刊文献

中文题名：The molecular dynamics of neural metabolism during the action potential

英文题名：The molecular dynamics of neural metabolism during the action potential

作者：Zheng HongWen[1];Wang RuBin[1];Qiao LinKun[2];Du Ying[1]

机构：[1]E China Univ Sci & Technol, Inst Cognit Neurodynam, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Biol Engn, Shanghai 200237, Peoples R China

年份：2014

卷号：57

期号：5

起止页码：857

中文期刊名：Science China(Technological Sciences)

外文期刊名：SCIENCE CHINA-TECHNOLOGICAL SCIENCES

收录：;EI(收录号：20142217759442);Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000335903500001)】；

基金：This work was supported by the National Natural Science Foundation of China(Grant Nos. 11232005, 11002055) and the Ministry of Education Doctoral Foundation (Grant No. 20120074110020).

语种：英文

中文关键词：neural energy;action potential;ion channels;astrocytes;hyperaemia

外文关键词：neural energy; action potential; ion channels; astrocytes; hyperaemia

摘要：Neural information processing is tightly coupled to both energy consumption and derivation from substrates.In this study,the energy function of the neuron during the action potential(AP)is described and analyzed.It has been observed that energy consumption during the AP does not match predictions of the conventional theory of neural energy dynamics.On short time scales,neural energy expenditure shifts between positive and negative phases.During the AP,the energy source switches from neuronal stores(positive expenditure or net consumption)to exploitation of external substrates,specifically the glucose and oxygen carried in cerebral blood(the negative consumption phase).Based on the idea of reductionism,this paper demonstrates how ion channels,membrane pumps and transporters,ionotropic and metabotropic receptor signaling pathways,astrocyte glycolysis and the production lactate,and the glutamate-glutamine cycle all serve to relate cerebral blood flow and neuronal metabolism to neuronal activity and so maintain neuronal energy charge during the AP.
Neural information processing is tightly coupled to both energy consumption and derivation from substrates. In this study, the energy function of the neuron during the action potential (AP) is described and analyzed. It has been observed that energy consumption during the AP does not match predictions of the conventional theory of neural energy dynamics. On short time scales, neural energy expenditure shifts between positive and negative phases. During the AP, the energy source switches from neuronal stores (positive expenditure or net consumption) to exploitation of external substrates, specifically the glucose and oxygen carried in cerebral blood (the negative consumption phase). Based on the idea of reductionism, this paper demonstrates how ion channels, membrane pumps and transporters, ionotropic and metabotropic receptor signaling pathways, astrocyte glycolysis and the production lactate, and the glutamate-glutamine cycle all serve to relate cerebral blood flow and neuronal metabolism to neuronal activity and so maintain neuronal energy charge during the AP.