文献类型：期刊文献

英文题名：A fast-response and highly specific Si-Rhodamine probe for endogenous peroxynitrite detection in living cells

作者：Tang, Junma[1,2];Li, Qiang[1,2];Guo, Zhiqian[1,2];Zhu, Weihong[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2019

卷号：17

期号：7

起止页码：1875

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20190806520248);WOS:【SCI-EXPANDED(收录号:WOS:000458679200042)】；

基金：This work was supported by National Key Research and Development Program (No. 2017YFC0906902), Excellent Young Scholars (21622602), Key Project (21636002), NSFC/China, Oriental Scholarship, Scientific Committee of Shanghai (14ZR1409700 and 15XD1501400), the Fundamental Research Funds for the Central Universities, Open Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：英文

外文关键词：Probes - Silicon compounds - Nitrogen compounds

摘要：Peroxynitrite (ONOO-) is involved in a variety of physiological and pathological processes. We designed and synthesized a fluorescent probe SiNH based on Si-rhodamine. The nanoprobe SiNH encapsulated within the amphiphilic copolymer exhibited fast response within 10 s, and it was highly specific for ONOO-in aqueous solution. It is demonstrated that the nanoprobe SiNH is applicable for real-time tracing of endogenous ONOO-in living cells.