文献类型：期刊文献

中文题名：B细胞超抗原及其免疫学特性

英文题名：B lymphyocyte superantigen and its immunological properties

作者：廉慧锋[1];马兴元[2]

机构：[1]山西出入境检验检疫局,太原030024;[2]华东理工大学生物工程学院,上海200237

年份：2005

卷号：21

期号：B06

起止页码：65

中文期刊名：免疫学杂志

外文期刊名：Immunological Journal

收录：CSTPCD;;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：B细胞超抗原;抗原特征;B细胞激活;免疫谱库选择

外文关键词：B lymphocyte superantigen; Antigen property; B lymphocyte stimulation; Immunoglobulin repertoire selection

摘要：B细胞超抗原是一类主要由细菌和病毒产生的,能够非特异地刺激B细胞大量增殖,并促进其合成免疫球蛋白的抗原。其激活B细胞的机理与普通抗原和B细胞丝裂原显著不同,不同微生物超抗原的特征与这些微生物的致病机制有密切关系。本文就目前研究比较多的几种B细胞超抗原的基本特征、免疫学特性及其对B淋巴细胞的作用机制与分子基础进行了综述,讨论了B-sAg在免疫谱库选择中的作用及其与一些疾病的关系。
B lymphocyte superantigen(B-SAg) is mainly produced by pathogenic bacteria and virus. B-SAg can stimulate the proliferation of B lymphocyte in a non-specific manner, thus promotes the synthesis of immunoglobulin. The activation mechanism of B lymphyocytes by B-SAg is significantly different from that of usual antigen and B lymphocyte mitogen. The characteristics of B-SAg from different disease-causing bacteria are closely linked to their own pathogenicity. This paper reviewed the primary characteristics, immunological properties, and the molecular mechanism of some kinds of B-Sag, which have attracted much attention in recent years. Roles of B-SAg in the selection of immunoglobulin repertoire and the relationship between B-SAg and some diseases are also discussed.