文献类型：期刊文献

英文题名：Dual Role of Aryl Iodide in Cascade C-H Arylation/Amination: Arylation Reagent and Cocatalyst for C-N Formation

作者：Li, Deng-Yuan;Liu, Shuo;Chen, Shuang;Wang, An;Zhu, Xiao-Ping;Liu, Pei-Nian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Meilong Rd 130, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, Meilong Rd 130, Shanghai 200237, Peoples R China

年份：2018

卷号：8

期号：7

起止页码：6407

外文期刊名：ACS CATALYSIS

收录：;EI(收录号：20182505352541);WOS:【SCI-EXPANDED(收录号:WOS:000438475100077)】；

基金：This research was supported by the National Natural Science Foundation of China (Project Nos. 21602059, 21421004, 21672059, and 21561162003), the Eastern Scholar Distinguished Professor Program, the China Postdoctoral Science Foundation (No. 2016T90341) and the Programme of Introducing Talents of Discipline to Universities (No. B16017).

语种：英文

外文关键词：cocatalysis; aryl iodides; primary amines; C-H amination; cascade reactions

摘要：A cascade C-H arylation/amination protocol using homoallylic primary amines as the starting materials in the presence of a palladium catalyst produces 2-aryl-1-pyrrolines with excellent regioselectivity and in good yields. Mechanistic studies indicate that this transformation proceeds via palladium-catalyzed Heck coupling, C-H amination, and tautomerization. As an unprecedented example of aryl iodide acting as an arylation reagent and a cocatalyst, the key role of aryl iodide as a cocatalyst is to generate the active bivalent aryl palladium catalyst to promote C-N formation during the C-H amination step.