文献类型：期刊文献

英文题名：Expedient synthesis of the tetracyclic core of ent-nakadomarin a

作者：Deng, Haibing[1];Yang, Xiaobao[1,2];Tong, Zhaolong[1];Li, Zhong[2];Zhai, Hongbin[1]

机构：[1]Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Modern Synth Organ Chem, Shanghai 200032, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2008

卷号：10

期号：9

起止页码：1791

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000255311200031)，CCR-EXPANDED(收录号:WOS:000255311200031)】；

语种：英文

摘要：An efficient eight-step assembly of the tetracyclic core (ABCD rings) of ent-(+)-nakadomarin A, a bioactive hexacyclic marine alkaloid, has been realized with Sonogashira coupling, platinum(II)-promoted cascade cyclizations, and saturation of a challenging carbon - carbon double bond through a hydroboration/oxidation/xanthate formation/Barton - McCombie deoxygenation sequence as key transformations.