文献类型：期刊文献

英文题名：Endogenous Electric Field-Driven Neuro-Immuno-Regulatory Scaffold for Effective Diabetic Wound Healing

作者：Liu, Zhiqing[1]; Wang, Tianlong[1]; Zhao, Jinhui[1]; Zhang, Lei[1]; Luo, Yiping[1]; Chen, Yixing[1]; Wu, Xinhui[1]; Liu, Yaqi[1]; Aierken, Aihemaitijiang[1]; Duolikun, Dilixiati[1]; Jiang, Hui[1]; Zhao, Xinyu[1]; Li, Chang[1]; Li, Yingchuan[5]; Cao, Wentao[4]; Du, Jianzhong[1,6,7]; Zheng, Longpo[1,2,3]

机构：[1] Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; [2] Shanghai Trauma Emergency Center, Shanghai, 200072, China; [3] Orthopedic Intelligent Minimally Invasive Diagnosis & Treatment Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; [4] Department of Prosthodontics, Shanghai Stomatological Hospital, School of Stomatology, Fudan University, Shanghai, 201102, China; [5] Department of Critical Care Medicine, School of Medicine, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China; [6] Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, 4800 Caoan Road, Shanghai, 201804, China; [7] School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China

年份：2024

外文期刊名：SSRN

收录：EI(收录号：20240485213)

语种：英文

外文关键词：Brain - Electrotherapeutics - Scaffolds - Scaffolds (biology) - Surface discharges - Tissue regeneration

摘要：The pathological microenvironment in diabetic wounds is delineated by heightened inflammatory responses and persistent proinflammatory macrophage activity, which significantly hinders the wound healing process. Exogenous electrical stimulation (ES), by modulating the electric field distribution in wounds, has shown significant potential in treating inflammatory wounds. However, this approach relies on additional power sources and complex circuit designs. Here, a bionic neuro-immuno-regulatory (BNIR) system was proposed for reshaping the endogenous electric fields (EFs) through collecting ion flow. The BNIR system comprises microporous structure scaffolds and nanosheets, enabling swift biofluid collection and electrical signal transmission, with the ability to promote cell proliferation and migration and exhibit antioxidant properties. More importantly, the BNIR system induced the transition of M1 macrophages to M2 macrophages through neuro-immuno-regulatory. In diabetic rat skin wounds, the BNIR system significantly enhanced healing by simultaneously neuro-immuno-regulatory, promoting angiogenesis, scavenging ROS, and facilitating tissue remodeling. This work aims to advance the development of bionic system for electrosensitive tissues repair. ? 2024, The Authors. All rights reserved.