文献类型：期刊文献

英文题名：NIR-Triggered "OFF/ON" Photodynamic Therapy through a Upper Critical Solution Temperature Block Copolymer

作者：Jiang, Dawei[1];Chen, Chao[2];Xue, Yudong[1];Cao, Hongliang[1];Wang, Chaochao[1];Yang, Guoliang[1];Gao, Yun[1];Wang, Ping[2,3];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Funct Mat Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg, State Key Lab Bioreactor Engn, Biomed Nanotechnol Ctr,Sch Biotechnol, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Univ Minnesota, Bioprod & Biosyst Engn, 2004 Folwell Ave, St Paul, MN 55108 USA

年份：2019

卷号：11

期号：40

起止页码：37121

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20194107512336);WOS:【SCI-EXPANDED(收录号:WOS:000490357900090)】；

基金：This work was financially supported by the National Natural Science Foundation of China (Nos. 21574039 and 21875063) and the Shanghai Natural Science Foundation (18ZR1408300).

语种：英文

外文关键词：photodynamic therapy; upper critical solution temperature; porphyrin; block copolymer; IR780; fluorescence resonance energy transfer

摘要：Activatable photodynamic therapy (A-PDT) has attracted great attention in precision medicine, which can be activated by endogenous or exogenous stimuli to selectively produce reactive oxygen species (ROS) at the disease site. Thermal responsive polymers with a lower critical solution temperature (LCST) have normally been utilized for constructing A-PDT system. Herein, we fabricated a photothermal activatable photosensitizer (A-PS) by the combination of thermal responsive porphyrin-containing P(AAm-co-AN-co-TPP)-b-PO-EGMA amphiphilic block copolymer with an upper critical solution temperature (UCST) of 42 degrees C and a cyanine dye of IR780. The photoactivity of porphyrin units could be severely inhibited by IR780 due to the fluorescence resonance energy transfer (FRET) from TPP to IR780 during blood circulation process ("OFF" state). After an uptake by A549 cells and then irradiated with 808 nm laser, A-PS nanoparticles were subsequently dissociated owing to the increased local temperature above the UCST of the polymer chains by excellent photothermal conversion of IR780, resulting in the enhanced photoactivity of TPP ("ON" state) and the remarkable antitumor effect. Therefore, the UCST-based A-PS extended the biological application of thermal responsive polymers, which may provide a new insight into the design of smart cancer therapeutic systems.