文献类型：期刊文献

英文题名：A Bronsted acid-promoted asymmetric intramolecular allylic amination of alcohols

作者：Zhou, Jianqiao[1];Xie, Hexin[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2018

卷号：16

期号：3

起止页码：380

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000423025400006)】；

基金：We are grateful to the "Thousand Plan" Youth Program, the Fundamental Research Funds for the Central Universities, and East China University of Science & Technology for financial support.

语种：英文

摘要：Reported herein is a chiral Bronsted acid-catalyzed asymmetric intramolecular allylic amination reaction, allowing facile access to a range of biologically interesting chiral 2-substituted hydroquinolines in up to 90% yield and with up to 93% ee. Furthermore, a significant effect of an N-protecting group was observed in this asymmetric process.