文献类型：期刊文献

英文题名：Spherical polyelectrolyte nanogels as templates to prepare hollow silica nanocarriers: observation by small angle X-ray scattering and TEM

作者：Han, Haoya[1];Li, Li[1];Tian, Yuchuan[1];Wang, Yunwei[1];Ye, Zhishuang[1];Yang, Qingsong[1];Wang, Yiming[1,2];von Klitzing, Regine[3];Guo, Xuhong[1,4]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Delft Univ Technol, Dept Chem Engn, NL-2629 HZ Delft, Netherlands;[3]Tech Univ Darmstadt, Dept Phys, Alarich Weiss Str 10, D-64287 Darmstadt, Germany;[4]Shihezi Univ, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Xinjiang 832000, Peoples R China

年份：2017

卷号：7

期号：76

起止页码：47877

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20174404327740);WOS:【SCI-EXPANDED(收录号:WOS:000413528700002)】；

基金：We gratefully thank the financial support from the NSFC Grants (51273063 and 21476143), the Fundamental Research Funds for the Central Universities, 111 Project Grant (B08021), Shanghai Synchrotron Radiation Facility, and the China Scholarship Council.

语种：英文

外文关键词：Targeted drug delivery - Controlled drug delivery - Polyelectrolytes - X ray scattering - Polyethylenes - Silica nanoparticles

摘要：Hollow silica nanoparticles were prepared through generating a silica layer in spherical polyelectrolyte nanogels (SPN), which consisted of a solid core of polystyrene (PS) and a shell of crosslinked poly(acrylic acid) (PAA), followed by removing the PS core via solvent dissolution. Small angle X-ray scattering (SAXS) in combination with TEM were employed to observe SPN, silica-polymer composite, and hollow silica nanoparticles. It was confirmed that SAXS is a powerful method to monitor the generation of silica layer in SPN. The density and thickness of generated silica layer in SPN were found to be tunable by controlling the crosslinking density of the templates. The porous structure and pH sensitivity of silica layer allowed the obtained hollow silica to be ideal carriers for controlled drug delivery.