文献类型：期刊文献

英文题名：Enantioseparation of racemic aminoglutethimide using asynchronous simulated moving bed chromatography

作者：Lin, Xiaojian[1];Gong, Rujin[1];Li, Jiaxu[1];Li, Ping[1];Yu, Jianguo[1];Rodrigues, Alirio E.[2]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Coll Chem Engn, Shanghai 200237, Peoples R China;[2]Univ Porto, LSRE, Associate Lab LSRE LCM, Dept Chem Engn,Fac Engn, Rua Dr Roberto Frias S-N, P-4200465 Oporto, Portugal

年份：2016

卷号：1467

起止页码：347

外文期刊名：JOURNAL OF CHROMATOGRAPHY A

收录：;EI(收录号：20164202913229);WOS:【SCI-EXPANDED(收录号:WOS:000385323800032)】；

基金：This study is financially supported by the National Natural Science Foundation of China (Grant No. 21276080, No.21376085).

语种：英文

外文关键词：Enantioseparation; Aminoglutethimide enantiomers; VARICOL process; SMB process; Modeling; Chromatographic separation

摘要：The separation of aminoglutethimide enantiomers by the continuous multicolumn chromatographic processes were investigated experimentally and theoretically, where the columns were packed with cellulose tris 3,5-dimethylphenyl-carbamate stationary phase (brand name Chiralcel OD) and mobile phase was a mixture of n-hexane and ethanol with monoethanolamine additive. The continuous enantioseparation processes included a synchronous shifting process (SMB) and an asynchronous shifting process (VARICOL), which allowed reducing the column number (here from six-column SMB to five-column VARICOL process). Transport-dispersive model with the consideration of both intraparticle mass transfer resistance and axial dispersion was adopted to design and optimize the operation conditions for the separation of aminoglutethimide enantiomers by SMB process and VARICOL process. According to the optimized operation conditions, experiments were carried out on VARICOL-Micro unit using five-column VARICOL process with 1/1.5/1.5/1 configuration and six-column SMB process with 1/2/2/1 configuration. Products of R-aminoglutethimide (R-AG) enantiomer and S-aminoglutethimide (S-AG) enantiomer with more than 99.0% purity were obtained continuously from extract stream and raffinate stream, respectively. Furthermore, the experiemntal data obtained from five-column VARICOL process were compared with that from six-column SMB process, the feasibility and efficiency for the separation of guaifenesin enantiomers by VARICOL processes were evaluated. (C) 2016 Elsevier B.V. All rights reserved.