文献类型：期刊文献

英文题名：Gold nanostructures for cancer imaging and therapy

作者：Gao, Y.[1]; Li, Y.[1]

机构：[1] East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China

年份：2016

卷号：6

起止页码：53

外文期刊名：Springer Series in Biomaterials Science and Engineering

收录：EI(收录号：20212810630996)

语种：英文

外文关键词：Tumors - Surface plasmon resonance - Computerized tomography - Infrared devices - Nanoribbons - Light - Surface scattering - Diseases - Gold compounds - Sulfur compounds - Chemotherapy - Optical tomography - Gold - Medical imaging - Photodynamic therapy - Raman scattering

摘要：Gold nanostructures can manipulate light at the nanoscale based on the optical phenomenon widely known as localized surface plasmon resonance (LSPR). Upon light excitation, specific gold nanostructures are supposed to preferentially absorb or scatter light in the near-infrared (NIR) region, which enable them applicable as imaging and therapeutic agents. Furthermore, facile surface functionaliza-tion via Au-S bonding makes gold nanostructures as universal substrates to attach functional molecules, drug cargo, and targeting ligands. Together with their easy synthesis and non-toxicity, gold nanostructures have emerged as a greatly promising platform in cancer diagnostics and treatment. This chapter summarizes the progress made in cancer imaging and therapy with gold nanostructures (1) as therapeutic components for photothermal therapy, photodynamic therapy, chemotherapy, and their combination; (2) as probes for various imaging techniques including dark-field, optical coherence tomography, two-photon luminescence, photoacoustic imaging, computed tomography, and surface-enhanced Raman scattering based imaging; and (3) as a theranostic platform for imaging-guided therapy. ? Springer-Verlag Berlin Heidelberg 2016.