文献类型：期刊文献

英文题名：Phragmalin-Type Limonoids from the Fruits of Chukrasia tabularis and Their Anti-Inflammatory Activity

作者：Dai, Shujun[1];Wu, Yuzhen[1];Xin, Xiujuan[1];An, Faliang[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Marine Biomed Sci & Technol Innovat Platform Lin G, 4, Lane 218, Haiji Sixth Rd, Shanghai 201306, Peoples R China

年份：2023

卷号：28

期号：13

外文期刊名：MOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001028558000001)】；

基金：This work was funded by the National Natural Science Foundation of China (41876189, 81703388). This work was also supported by State Key Laboratory of Bioreactor Engineering and the Open Research Fund Program of Institute of regulatory science.

语种：英文

外文关键词：Chukrasia tabularis; meliaceae; limonoid; anti-inflammatory

摘要：Phytochemical investigation on the fruits of C. tabularis led to the isolation of five new phragmalin-type limonoids (1-5) and four known ones (6-9). The structures of the new compounds 1-5, named chuktabamalins A-E, were elucidated via spectroscopic techniques (HRESIMS, 1D and 2D NMR) and were comparable with the literature data of known compounds. In addition, new compounds were evaluated for in vitro anti-inflammatory activity. Compounds 1, 2, 3 and 5 showed moderate anti-inflammatory activity with IC50 values of 21.72 & PLUSMN; 2.79, 23.29 & PLUSMN; 1.00, 47.08 & PLUSMN; 3.47 and 66.67 & PLUSMN; 2.89 & mu;M, respectively.