文献类型：期刊文献

英文题名：Spray-Assisted Coil-Globule Transition for Scalable Preparation of Water-Resistant CsPbBr3@PMMA Perovskite Nanospheres with Application in Live Cell Imaging

作者：Wang, Yuanwei[1];Varadi, Linda[2];Trinchi, Adrian[2];Shen, Jianhua[1];Zhu, Yihua[1];Wei, Gang[1,3];Li, Chunzhong[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Commonwealth Sci & Ind Res Org, Mfg, Res Way,Private Bag 10, Clayton, Vic 3168, Australia;[3]Commonwealth Sci & Ind Res Org, Mfg, 36 Bradfield Rd West,POB 218, Lindfield, NSW 2070, Australia

年份：2018

卷号：14

期号：51

外文期刊名：SMALL

收录：;EI(收录号：20184706108323);WOS:【SCI-EXPANDED(收录号:WOS:000453859100004)】；

基金：This work was supported by the National Natural Science Foundation of China (Grant Nos. 21471056, 21676093, 91534202, 21776092). The authors appreciated Dr. Michael Breedon for his effort in building up the spray instrument. The authors gratefully acknowledged the financial support from the China Scholarship Council.

语种：英文

外文关键词：cell imaging; coil-globule transition; perovskite; quantum dots; spray

摘要：Despite their impressive optical properties, lead halide perovskite quantum dots (PQDs) have not realized their potential, especially in bioimaging applications, as they suffer from poor moisture and thermal stability, solvent incompatibility, and significant toxicity. Here, a spray-assisted coil-globule transition method for encapsulating CsPbBr3 (CPB) PQDs into poly(methyl methacrylate) (PMMA) polymer nanospheres is reported. Polyvinylpyrrolidone-capped CPB PQDs are synthesized via the ligand assisted reprecipitation method in dichloromethane. After dissolving PMMA, the above precursor solution is sprayed into petroleum ether under high pressure N-2. High-pressure nebulization restricts the interactions between PMMA polymer chains, resulting in the formation of approximate to 112 nm nanoscale composite spheres after a coil-globule transition. The CPB@PMMA nanospheres not only possess 73% quantum yields but retain 81% of fluorescence intensity after the exposure to water for over 80 days. Due to their confined size and biocompatible encapsulation, they are readily available for cellular uptake and exhibit no toxicity on live HeLa cells. Furthermore, the PMMA surface allows for functional surface modification, carrying the possibility of targeting specific biological species and processes.