文献类型：期刊文献

英文题名：Peptide Polymer-Doped Cement Acting as an Effective Treatment of MRSA-Infected Chronic Osteomyelitis

作者：Wu, Yueming[1];Lin, Yaofa[2,3];Cong, Zihao[4];Chen, Kang[4];Xiao, Ximian[4];Wu, Xue[4];Liu, Longqiang[4];She, Yunrui[4];Liu, Shiqi[4];Zhou, Ruiyi[4];Yin, Gang[2,3];Shao, Xiaoyan[5];Dai, Yidong[5];Lin, Haodong[2,3];Liu, Runhui[1,4]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Orthoped Surg, Shanghai 200080, Peoples R China;[3]Shanghai Gen Hosp, Jiading Branch, Shanghai 201803, Peoples R China;[4]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Frontiers Sci Ctr Materiobiol & Dynam Chem,Res Ct, Shanghai 200237, Peoples R China;[5]Shanghai Ruijin Rehabil Hosp, Shanghai 200023, Peoples R China

年份：2022

卷号：32

期号：7

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20214511127749);WOS:【SCI-EXPANDED(收录号:WOS:000714624600001)】；

基金：Y.W. and Y.L. contributed equally to this work. This research was supported by the National Natural Science Foundation of China (No. 21774031, 31800801), the Program of Outstanding Medical Talent of Shanghai Municipal Health Bureau (No. 2017BR034), Program of Shanghai Academic/Technology Research Leader (20XD1421400), Research program of State Key Laboratory of Bioreactor Engineering, and the Fundamental Research Funds for the Central Universities (2221818014). The authors thank the beamline BL13W of the Shanghai Synchrotron Radiation Facility (SSRF, Shanghai, People's Republic of China) for the help with the micro-CT analysis. The authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization. All animal-related operations in this work were approved by the Animal Care and Use Committee of Shanghai General Hospital.

语种：英文

外文关键词：antibacterial; chronic osteomyelitis; host defense peptides; MRSA; peptide polymers

摘要：Chronic osteomyelitis is a painful and serious disease normally caused by infected surgical prostheses or infected fractures. Currently, antibiotic-loaded cements are extensively used as the treatment in clinical practice. However, the quick emergence of antibiotic-resistant bacteria has resulted in a formidable challenge in treating chronic osteomyelitis, such as the chronic osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA). Aiming to address MRSA-infected chronic osteomyelitis, an antibacterial peptide polymer doped polymethylmethacrylate bone cement pellets (PMMA@polymer) is prepared. The peptide polymer is designed as the synthetic mimic of host defense peptide and enables PMMA@polymer to have notable advantages, including complete release of antibacterial agent from PMMA, potent and robust activity against MRSA even after autoclave and enzymatic treatment, and low susceptibility to antibacterial resistance. PMMA@polymer showed potent in vitro activities against MRSA, superior in vivo therapeutic efficacy in a rabbit chronic osteomyelitis model, and low toxicity during the treatment. These advantages and the easy preparation of PMMA@polymer altogether suggest the great potential of PMMA@polymer as an effective treatment of MRSA-infected chronic osteomyelitis. This study opens new avenues in developing antibacterial biomaterials for the treatment of chronic orthopedic infections, frequently caused by drug-resistant bacteria.