文献类型：期刊文献

英文题名：Diastereomeric Resolution of p-Chloromandelic Acid with (R)-Phenylethylamine

作者：He, Quan[3];Peng, Yang-Feng[2];Rohani, Sohrab[1]

机构：[1]Univ Western Ontario, Dept Chem & Biochem Engn, London, ON N6A 5B9, Canada;[2]E China Univ Sci & Technol, Dept Chem Engn, Shanghai 200237, Peoples R China;[3]Ningbo Univ Technol, Dept Chem Engn, Ningbo 315016, Zhejiang, Peoples R China

年份：2010

卷号：22

期号：1

起止页码：16

外文期刊名：CHIRALITY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000273192200003)】；

基金：Contract grant sponsor: Ningbo Nature Science Fund; Contract grant number: 2005B100085

语种：英文

外文关键词：p-chloromandelic acid; phenylethylamine; resolution; diastereomeric salt; crystal structure; binary melting point phase diagram

摘要：The optical resolution of p-chloromandelic acid using (R)-alpha-phenylethylamine as resolving agent was presented. The effect of solvents, molar ratio of racemate to the resolving agent, filtration temperature as well as the amount of solvent on resolution was investigated by orthogonal experimentation. The binary melting point phase diagram and crystal structure analysis of diastereomeric salts rationalized the success of the resolution. Chirality 22:1.6-23, 2010. (C) 2009 Wiley-Liss, Inc.