文献类型：期刊文献

中文题名：赖氨酸流加发酵最优控制的研究

英文题名：Optimization of Lysine Fed-batch Fermentation

作者：宫衡[1];伦世仪[2]

机构：[1]华东理工大学生化工程系,上海200237;[2]无锡轻工大学生物工程系,无锡214036

年份：1996

卷号：12

期号：4

起止页码：482

中文期刊名：生物工程学报

外文期刊名：Chinese Journal of Biotechnology

收录：CSTPCD;;Scopus;北大核心:【北大核心1992】；CSCD:【CSCD2011_2012】；PubMed;

语种：中文

中文关键词：赖氨酸;发酵;流加发酵;最优化

外文关键词：Lysine fermentation, fed-batch fermentation, optimization

摘要：在赖氨酸发酵动力学模型和庞特里金明小值原理的基础上,得出流加发酵的最优化底物流加方式。并进一步对流加发酵的全过程进行了分析,得出了在实际控制中较为可行的流加发酵全过程的总控制策略,实际控制表明在小型反应器中赖氨酸产生菌FB42的发酵水平为81.6g/L、转化率为0.418％、生产强度为1.16g/h·L,和分批发酵相比分别提高了45.4％、9.7％和28.4％。
Based on kinetics of lysine fermentation and minimum principle of Pontryagin's, the optimal policy for fed-batch lysine fermentation has been formulated and calculated. The lysine process including initial batch period and fed period was then comprehensively analyzed, and a total control strategies was established successfully. The prectical results indicated: the lysine produce level, overall yield and productivity of Fb42 from fed-batch fermentation of in a 30L bioreactor reached 81. 6g/L, 0. 418 and 1. 16g/h - L, which was higher than that of the batch fermentation by 45. 4% .9. 7% and 28.3%.