文献类型：期刊文献

英文题名：Music therapy in modulating immune responses and enhancing cancer treatment outcomes

作者：Fu, Ye[1];Wu, Ke[2];Zhuang, Jiajia[3];Chen, Yisheng[3];Jia, Lina[4];Luo, Zhiwen[5,6,7];Sun, Rong[8]

机构：[1]East China Univ Sci & Technol, Inst Marxism, Div Moral & Legal Educ, Shanghai, Peoples R China;[2]Kangwon Natl Univ, Chunchon, South Korea;[3]Ningde Normal Univ, Ningde Municipal Hosp, Ningde, Fujian, Peoples R China;[4]Hebei Med Univ, Dept Orthopaed, Shijiazhuang, Hebei, Peoples R China;[5]Fudan Univ, Huashan Hosp, Dept Sports Med, Shanghai, Peoples R China;[6]Fudan Univ, Dr Kong Joint Lab Sports Med, Shanghai, Peoples R China;[7]Jiaxing Univ, Affiliated Hosp 2, Sports Hosp Jiaxing, Dept Orthopaed, Jiaxing, Zhejiang, Peoples R China;[8]Nanjing Univ, Jinling Hosp, Affiliated Hosp, Dept Radiat Oncol,Med Sch, Nanjing, Peoples R China

年份：2025

卷号：16

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001544008300001)】；

语种：英文

外文关键词：music therapy; cancer; immune modulation; inflammation; integrative oncology; neuroimmune interaction; tumor microenvironment; single-cell resolution

摘要：Music therapy, an intersection of art and science, is gaining recognition as a complementary approach in cancer care. This review systematically explores its mechanisms, applications, and effectiveness, with a focus on its impact on the tumor microenvironment (TME), particularly immune signaling and inflammation at single-cell resolution. Evidence shows that music therapy alleviates psychological symptoms-such as anxiety and depression-and physical discomforts including pain, fatigue, and nausea. Beyond symptomatic relief, it also modulates immune responses, especially in immune cell populations that influence tumor-associated inflammation and cancer progression. Advances in single-cell technologies may begin to explain how music therapy modulates immune signaling pathways within the TME, potentially enhancing treatment efficacy.Despite its non-invasive, cost-effective nature and high patient acceptability, music therapy remains underutilized in oncology. Further large-scale studies are needed to elucidate its molecular mechanisms, refine intervention models, and validate its role in immune modulation. As research advances, music therapy holds promise as a valuable component of integrative oncology, supporting patient recovery and immune homeostasis.