文献类型：期刊文献

英文题名：Development of asymmetric gradational-changed porous chitosan membrane for guided periodontal tissue regeneration

作者：Hong, Hua[1]; Wei, Jie[1]; Liu, Changsheng[1]

机构：[1]E China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2007

卷号：38

期号：3

起止页码：311

外文期刊名：COMPOSITES PART B-ENGINEERING

收录：;EI(收录号：20070510395548);WOS:【SCI-EXPANDED(收录号:WOS:000244292400005)】；

语种：英文

外文关键词：polymer-matrix composites (PMCs); mechanical properties; microstructures; biocompatibility

摘要：A novel kind of guided tissue regeneration (GTR) barrier membrane has been fabricated using an immersion-precipitation phase inversion technique (IPPI) with biodegradable natural polymer-chitosan. The membrane had an asymmetric gradational-changed porous structure including a dense skin layer, a transition region and a sponge-like porous layer. The concentration of chitosan solution and solvent evaporated time were two key factors that had significant effect on the porosity, average pore size, absorbed water ratio and mechanical properties of the porous membrane. The porous membrane not only degraded but maintaining the structure integrity for 5-6 weeks in the enzyme solution that can meet the demand for GTR. The biological experiment results showed the asymmetric membranes did not cause anaphylactic reaction, hemolysis, cytotoxicity and pyrogenic effect. All of the results indicated that the porous chitosan membrane had excellent biocompatibility and biodegradation, which could be used as a barrier for preventing apical migration of gingival epithelial cells and promoting growth of periodontal ligament cells in periodontal therapy. (c) 2006 Elsevier Ltd. All rights reserved.