文献类型：期刊文献

英文题名：Melting Behavior of Zipper-Structured Lipopeptides in Lipid Bilayer

作者：Wang, Sijia;Han, Xia;Liu, Danyang;Li, Mengya;Xu, Shouhong[1];Liu, Honglai[1]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2017

卷号：33

期号：6

起止页码：1478

外文期刊名：LANGMUIR

收录：;EI(收录号：20170803359661);WOS:【SCI-EXPANDED(收录号:WOS:000394411100019)】；

基金：Financial support for this work is provided by the National Natural Science Foundation of China (No. 21276074, No. 21376073), the 111 Project (No. B08021) of China, and the Fundamental Research Funds for the Centre Universities of China.

语种：英文

外文关键词：Fluidity - Molecular structure - Phospholipids - Targeted drug delivery - Liposomes - Controlled drug delivery - Melting

摘要：A zipper-structured lipopeptide is expected to play a role of "intelligent valve" in the lipid bilayer. In this paper, a series of zipper-structured lipopeptides have been designed for preparing thermocontrollable hybrid liposomes. Their conformational transition as a function of temperature in lipid bilayer has been investigated for understanding the influences of molecular structure and bilayer property on biofunction. The melting temperatures T-m of the lipopeptides have been found to depend on their molecular structures. When the lipopeptides have been doped in bilayer, an increase of size of alkyl chain increases the stability of the a-helix resulting in a decrease in fluidity of lipid bilayer. However, an increase of amino groups at N-terminal is found to decrease the stability of the spatial structure. The thermocontrollability of the "valve" in lipid bilayer is confirmed by drug release experiments under different temperatures. Meanwhile, effects of bilayer properties on the thermosensitivity of lipopeptides have also been investigated. Results show the T-m of lipopeptide doped in bilayer decreases with the increase of membrane fluidity. Furthermore, the reversibility of the thermocontrolled "valve" is also proven by release drug under intermittent temperatures. It could be concluded that the molecular structure of the lipopeptide, as well as the property of bilayer, give great influence on the biofunction of the hybrid liposomes.