文献类型：期刊文献

英文题名：Enantioselective Squaramide-Catalysed Domino Mannich-Cyclization Reaction of Isatin Imines

作者：Wang, Xi-Bo[1,2];Li, Tian-Ze[1,2];Sha, Feng[1,2];Wu, Xin-Yan[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2014

卷号：2014

期号：4

起止页码：739

外文期刊名：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000336261500007)，CCR-EXPANDED(收录号:WOS:000336261500007)】；

基金：The authors are grateful for the financial support from National Natural Science Foundation of China (NSFC) (grant number 21242007) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Organocatalysis; Asymmetric catalysis; Domino reactions; Nucleophilic addition; Oxygen heterocycles; Cyclization

摘要：An enantioselective domino reaction of 4-bromo-3-oxobutanoates with isatin-derived ketimines was developed to construct 3-amino-2-oxindoles with a quaternary stereocentre. In the presence of 1 mol-% of a bifunctional squaramide organocatalyst, the desired products were achieved in high yields (90-97%) and with excellent enantioselectivities (92-99% ee).