文献类型：期刊文献

英文题名：Cocrystals of flavonoids with 4,4′-ethylenebispyridine: Crystal structures analysis, dissolution behavior, and anti-tumor activity

作者：Zhang, Yanhong[2,3];Yang, Rui[2,3];Yin, He-Mei[2,3];Zhou, Bijian[2,3];Hong, Minghuang[2,3];Zhu, Bin[2,3];Qi, Ming-Hui[2,3];Ren, Guo-Bin[1,2,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Lab Pharmaceut Crystal Engn & Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2022

卷号：1252

外文期刊名：JOURNAL OF MOLECULAR STRUCTURE

收录：;EI(收录号：20215111371462);WOS:【SCI-EXPANDED(收录号:WOS:000744650100006)】；

基金：The authors thank the National Natural Science Foundation of China (Grants 21776073 and22078094) forsupport.

语种：英文

外文关键词：Tumors - Cancer cells - Single crystals - Dissolution

摘要：The concepts of crystal engineering was utilized to acquire cocrystals of EBP with flavonoids. Four cocrystals were synthesized and characterized, as well their single crystal structures were revealed. The powder dissolution profiles of the cocrystals were determined and the antitumor activities were analyzed and compared with the corresponding physical mixtures. The results showed that the cocrystals of Myr.EBP and Gen.EBP display better anti-tumor effect against HCT-8 and CaCO-2 cancer cells. (C) 2021 Elsevier B.V. All rights reserved.