文献类型：期刊文献

英文题名：A copper(I)-catalyzed asymmetric Mannich reaction of glycine Schiff bases with isatin-derived ketimines: enantioselective synthesis of 3-substituted 3-aminooxindoles

作者：Zhu, Jing-Yan[1,2];Yang, Wu-Lin[1,2];Liu, Yang-Zi[1,2];Shang, Shao-Jing[1,2];Deng, Wei-Ping[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：5

期号：1

起止页码：70

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20184806137393);WOS:【SCI-EXPANDED(收录号:WOS:000418375600013)，CCR-EXPANDED(收录号:WOS:000418375600013)】；

基金：This work is supported by the National Natural Science Foundation of China (No. 21372074 and 21572053).

语种：英文

外文关键词：Copper compounds - Catalysis - Enantioselectivity

摘要：A Cu(I)/Ph-Phosferrox complex catalyzed asymmetric Mannich reaction of glycine Schiff bases with isatin-derived ketimines has been described. This strategy can provide direct access to chiral 3-substituted 3-aminooxindoles bearing vicinal quaternary-tertiary carbon stereocenters in high yields (up to 99%), excellent enantioselectivities (up to >99% ee) and moderate to high diastereoselectivities (up to 98 : 2 dr).