文献类型：期刊文献

英文题名：Alginate oligosaccharides improve high-fat induced hepatic steatosis via PGC-1α-mediated lipophagy and fatty acid β-oxidation pathway

作者：Li, Zhuoyu[1];Zhao, Mengyao[1];Ji, Xiaoguo[1];Fan, Liqiang[1];Zhao, Liming[1,2]

机构：[1]East China Univ Sci & Technol, R&D Ctr Separat & Extract Technol Fermentat Ind, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Collaborat Innovat Ctr Biomfg Technol SCI, Shanghai 200237, Peoples R China

年份：2023

卷号：110

外文期刊名：JOURNAL OF FUNCTIONAL FOODS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001102936600001)】；

基金：This work was supported by Natural Science Foundation of Shanghai, China (23ZR1417300) , Shanghai Postdoctoral Excellence Program (2022153) and Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission) .

语种：英文

外文关键词：Alginate oligosaccharides (AOS); Non-alcoholic fatty liver disease (NAFLD); Lipid -lowering effect; PGC-1 alpha

摘要：This study explored the lipid-lowering effect and intervention mechanism of alginate oligosaccharides (AOS) on non-alcoholic fatty liver disease (NAFLD). Results showed that both unsaturated (UAOS) and saturated (SAOS) AOS improved the hepatic steatosis of NAFLD mice fed a high-fat diet (HFD). AOS promoted lipid catabolism in vivo and in vitro by activating the lipophagy and free fatty acid (FFA) 8 -oxidation pathways. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) represented the up-stream target of the FFA 8 -oxidation pathway and upregulated both in in vivo and in vitro, suggesting it might be the AOS intervention target. By activating or inhibiting PGC-1 alpha, AOS modulated the PGC-1 alpha activity to reduce hepatic lipid accumulation. Therefore, the results indicated that AOS exhibited a lipid-lowering effect via the PGC-1 alpha-mediated lipophagy-FFA 8 -oxidation transduction signal axis. These findings provided insight into using food-derived ingredients to intervene and treat chronic diseases involving lipid metabolism disorders.