文献类型：期刊文献

英文题名：A "crossbreeding" dyad strategy for bright and small-molecular weight near-infrared fluorogens: From the structural design to boost aggregation-induced emission

作者：Li, Juan[1];Zhao, Meiling[1];Huang, Jialiang[1];Liu, Pengqi[1];Luo, Xinyu[1];Zhang, Yutao[1];Yan, Chenxu[1];Zhu, Wei -Hong[1];Guo, Zhiqian[1]

机构：[1]East China Univ Sci & Technol, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat & Joint Int Res Lab Precis Chem &, Shanghai 200237, Peoples R China

年份：2022

卷号：473

外文期刊名：COORDINATION CHEMISTRY REVIEWS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000872220200001)】；

基金：This work was supported by NSFC/China (22225805, 21878087 and 21908060), National Key Research and Development Program (2021YFA0910000). Innovation Program of Shanghai Municipal Education Commission, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-28). Shanghai Municipal Science and Technology Major Project (Grant 2018SHZDZX03), Shanghai Science and Technology Committee Rising-Star Program (22QC1400400), Programme of Introducing Talents of Discipline to Universities (B16017).

语种：英文

外文关键词：Crossbreeding; Near-infrared; Fluorescent probe; Aggregation-induced emission; Bioimaging

摘要：The development of high-performance near-infrared fluorophores has gained tremendous attention for spatiotemporally in vivo dynamical bioimaging. The proposed pi-conjugated "crossbreeding" dyad strategy has led to the emergence of a new class of dyes with simple structure but stable, bright, and biocompatible. These dyads consist of two individual chromophores bridging via a short pi-conjugated bridge and tending to be identical in the delocalized system, thereby affording valuable new features not retaining their parent fluorophores in the photophysical properties. This review summarizes the crossbreeding dyad backbones and advances to bring forth small-molecular weight, high molar extinction coefficients, and outstanding chemical stability. Impressively, the crossbreeding AlEgens greatly expand NIR-II emission, high stability, and good brightness for in vivo imaging intact tissues and living animals. This crossbreeding strategy could pave a new way to construct high-performance NIR dyes, showing great potentials with the extensive endorsement of NIR-II bioimaging for clinic diagnosis. (C) 2022 Elsevier B.V. All rights reserved.