文献类型：期刊文献

英文题名：Factory-on-chip: Modularised microfluidic reactors for continuous mass production of functional materials

作者：Han, Tengteng[1];Zhang, Li[1,3];Xu, Hong[1,3];Xuan, Jin[2]

机构：[1]East China Univ Sci & Technol, Sch Mech & Power Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Heriot Watt Univ, Sch Engn & Phys Sci, Edinburgh EH14 4AS, Midlothian, Scotland;[3]Shanghai Inst Mat Genome, Shanghai 200237, Peoples R China

年份：2017

卷号：326

起止页码：765

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20172403768208);WOS:【SCI-EXPANDED(收录号:WOS:000406137200076)】；

基金：This work is supported by the National Basic Research Program of China (2014CB748500), the research grant (No. 16DZ2260600) from Science and Technology Commission of Shanghai Municipality, the Fundamental Research Funds for the Central Universities (222201717012, 222201718005) and The Global Innovation Initiatives Award (S-ECAGD-13-CA-149 (DT)).

语种：英文

外文关键词：Microfluidics; Microreactors; Scale-up; Factory-on-chip; Continuous synthesis

摘要：Droplet microfluidics provide an advanced platform for functional material synthesis. However, the process has been largely limited to the scale of laboratory study with the device known as lab-on-chip. Here, a multi-dimensional scale-up strategy based on modularised microfluidic reactors is presented to develop large-scale devices defined as factory-on-chip, achieving throughput enhancement to the industrial production scale. Under the guidance of the derived principle, an up-scaling system is demonstrated with eight microchannels parallelized to form an array, ten arrays stacked as the module, and five modules integrated in a system with 400 channels in total. Experiments showed that the circular array arrangement improved the uniformity of product droplets by 42.4% compared to that achieved with a parallel array. The stacking effect was also investigated with two types of material production systems. Chitosan/ TiO2 composite microspheres, as advanced wastewater treatment material, were continuously synthesized in mass production with a narrow size distribution of 3.59%, which could hardly be achieved with conventional methods. The material exhibited a methyl-orange dye removal efficiency of 65.3%, which constitutes an improvement of 10.8% compared to single-component chitosan microspheres. (C) 2017 Elsevier B.V. All rights reserved.