文献类型：期刊文献

英文题名：Control of Scaffold Degradation in Tissue Engineering: A Review

作者：Zhang, Hongbo[1];Zhou, Li[2];Zhang, Wenjun[1,2]

机构：[1]E China Univ Sci & Technol, Sch Mech & Power Engn, Complex & Intelligent Res Ctr, Shanghai 200237, Peoples R China;[2]Univ Saskatchewan, Dept Biomed Engn, Saskatoon, SK S7N 5A9, Canada

年份：2014

卷号：20

期号：5

起止页码：492

外文期刊名：TISSUE ENGINEERING PART B-REVIEWS

收录：;EI(收录号：20144900289308);WOS:【SCI-EXPANDED(收录号:WOS:000342562900009)】；

基金：The corresponding author wants to thank a partial financial support received from SHRF through a group phase I project, grant on "BioMEMS."

语种：英文

外文关键词：Scaffolds (biology) - Tissue regeneration

摘要：Tissue engineering has shown a great promise as a solution to the high demand for tissue and organ transplantations. Biomaterial scaffolds serve to house and direct cells to grow, exposing them to an adequate perfusion of nutrients, oxygen, metabolic products, and appropriate growth factors to enhance their differentiation and function. The degradation of biomaterial scaffolds is a key factor to successful tissue regeneration. In this article, the existing degradation control approaches in the context of scaffold tissue engineering were reviewed and a new paradigm of thinking called active control of scaffold degradation, proposed elsewhere by us, was also revisited and discussed in light of its benefit and requirement of this new technology.