文献类型：期刊文献

英文题名：One-pot synthesis of aromatic homoallylic alcohols from aldehydes and Grignard reagents promoted by Titanium(IV) tetraisopropanolate

作者：Song, Xiao-Nan[1];Lu, Lei[1];Hua, Si-Kai[1];Chen, Wei-Dong[1];Ren, Jiangmeng[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2014

卷号：70

期号：43

起止页码：7881

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000343344500006)，CCR-EXPANDED(收录号:WOS:000343344500006)】；

基金：This work was financially supported by National Natural Science Foundation of China (21302053). We are also grateful for the financial support from the Fundamental Research Funds for the Central University (WY1113007).

语种：英文

外文关键词：Titanium(IV) tetraisopropanolate; Grignard reagents; Homoallylic alcohols; Oxidative arylation

摘要：An efficient method of Titanium(IV) mediated one-pot reaction approaching aromatic homoallylic alcohols from aldehydes and dual Grignard reagents was developed with good isolated yields. This method could use aromatic-, heteroaromatic-, or aliphatic-aldehydes as starting materials. However, electronriched benzaldehyde or cinnamaldehyde tended to precede further hydroxyl eliminations to give all conjugated structures as demonstrated. (C) 2014 Elsevier Ltd. All rights reserved.