文献类型：期刊文献

英文题名：Parental co-exposure to bisphenol A and nano-TiO2 causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish offspring

作者：Guo, Yongyong[1];Chen, Lianguo[1];Wu, Juan[1];Hua, Jianghuan[1];Yang, Lihua[1];Wang, Qiangwei[2];Zhang, Wei[3];Lee, Jae-Seong[4];Zhou, Bingsheng[1]

机构：[1]Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China;[2]Zhejiang Univ, Inst Pesticide & Environm Toxicol, Hangzhou 310058, Zhejiang, Peoples R China;[3]East China Univ Sci & Technol, State Environm Protect Key Lab Environm Risk Asse, Sch Resource & Environm Engn, Shanghai 200237, Peoples R China;[4]Sungkyunkwan Univ, Dept Biol Sci, Coll Sci, Suwon 16419, South Korea

年份：2019

卷号：650

起止页码：557

外文期刊名：SCIENCE OF THE TOTAL ENVIRONMENT

收录：;EI(收录号：20183705799090);WOS:【SCI-EXPANDED(收录号:WOS:000447092700057)】；

基金：This work was supported by the National Natural Science Foundation of China [grant number 21577168], the Strategic Priority Research Program of the Chinese Academy of Sciences [grant number XDB14040103], and the State Key Laboratory of Freshwater Ecology and Biotechnology (2016FBZ11).

语种：英文

外文关键词：Bisphenol A; n-TiO2; Chronic co-exposure; Maternal transfer; Developmental neurotoxity and thyroid; disruption; Zebrafish

摘要：The coexistence of organic toxicants and nanoparticles in the environment influences pollutant bioavailability and toxicity. Using chronic co-exposure to an adult zebrafish model, this study investigated the transfer kinetics and transgenerational effects of bisphenol A (BPA) and titanium dioxide nanoparticles (n-TiO2) exposure in F1 offspring. When single and combined exposure to BPA (0, 2, and 20 mu g/L) and n-TiO2 (100 mu g/L) were compared, combined exposure was found to reciprocally facilitate bioaccumulation in adult fish while enhancing maternal transfer to offspring. Thyroid endocrine disruption and developmental neuroloxiciLy were observed in larval offspring by parental exposure to BPA alone or in combination with n-TiO2. Exposure to 20 mu g/L BPA significantly decreased the thyroxine (T4) concentration in adult plasma, leading to less transfer info the eggs. The presence of 20 mu g/L BPA with n-TiO2 further decreased the level of T4 compared lo BPA exposure alone. Additionally, offspring larvae derived from exposed parents exhibited lethargic swimming behavior. Overall, this study examined the interactions of BPA and n-TiO2 with regard lo their bioaccumulation, maternal transfer, and developmental effects, which highlighted that co-exposure dynamics are important and need to be considered for accurate environmental risk assessment. (C) 2018 Elsevier B.V. All rights reserved.