文献类型：期刊文献

英文题名：Rational design of peptides to overcome drug resistance by metabolic regulation

作者：Sun, Min[1,2];He, Le[2];Chen, Ran[3];Lv, Mingchen[3];Chen, Zhe-Sheng[4];Fan, Zhen[1,2];Zhou, Yuxiao[1];Qin, Jinlong[1,3];Du, Jianzhong[1,2,3]

机构：[1]Tongji Univ, Shanghai Peoples Hosp 4, Translat Res Inst Brain & Brain Like Intelligence, Sch Med,Dept Gynaecol & Obstet,Shanghai Key Lab An, Shanghai 200434, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, 4800 Caoan Rd, Shanghai 201804, Peoples R China;[4]St Johns Univ, Coll Pharm & Hlth Sci, Queens, NY 11439 USA

年份：2025

卷号：79

外文期刊名：DRUG RESISTANCE UPDATES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001423004700001)】；

基金：This research was supported by National Natural Science Foundation of China (52222306, 22075212, 21925505, 22335005 and 22305177) , international scientific collaboration fund of Science and Technology Commission of Shanghai Municipality (23520710900) , Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28) , the fellowship of China Postdoctoral Science Foundation (2022M720107, GZB20230517, 2024T170668) and Shanghai "Super Postdoc" Incentive Plan (2022568) , Shanghai Rising-Star Program (Sailing, 23YF1433000) . We thank Dr. Erik Jan Cornel's ( Ph.D. from University of Sheffield, United Kingdom) help of checking and rewriting the whole manuscript. J.D. is the recipient of National Science Fund for Distinguished Young Scholars.

语种：英文

外文关键词：Peptides; Self-assembling; Metabolism; Drug resistance; Metal ion

摘要：Chemotherapy is widely used clinically, however, its efficacy is often compromised by the development of drug resistance, which arises from prolonged administration of drugs or other stimuli. One of the driven causes of drug resistance in tumors or bacterial infections is metabolic reprogramming, which alters mitochondrial metabolism, disrupts metabolic pathways and causes ion imbalance. Bioactive peptide materials, due to their biocompatibility, diverse bioactivities, customizable sequences, and ease of modification, have shown promise in overcoming drug resistance. This review provides an in-depth analysis of metabolic reprogramming and associated microenvironmental changes that contribute to drug resistance in common tumors and bacterial infections, suggesting potential therapeutic targets. Additionally, we explore peptide-based materials for regulating metabolism and their potential synergic effect with other therapies, highlighting the mechanisms by which these peptides reverse drug resistance. Finally, we discuss future perspectives and the clinical challenges in peptidebased treatments, aiming to offer insights for overcoming drug-resistant diseases.