文献类型：期刊文献

英文题名：HIGHLY CHEMOSELECTIVE CONDENSATION OF β-NAPHTHOL, ALDEHYDE, AND UREA CATALYZED BY THIAMINE HYDROCHLORIDE

作者：Lei, Min[1];Ma, Lei[1];Hu, Lihong[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

年份：2011

卷号：41

期号：22

起止页码：3424

外文期刊名：SYNTHETIC COMMUNICATIONS

收录：;EI(收录号：20242616542935);WOS:【SCI-EXPANDED(收录号:WOS:000297976200017)，CCR-EXPANDED(收录号:WOS:000297976200017)】；

基金：This work was supported by the Chinese National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program" (Grants 2009ZX09301-001 and 2009ZX09102), the Chinese National High-Tech Research and Developed Program (Grant 2007AA02Z147), the National Natural Science Foundation of China (Grants 90713046, 30772638, and 30925040), and the CAS Foundation (Grant KSCX2-YW-R-179).

语种：英文

外文关键词：Catalysis; chemoselective; multicomponent reactions (MCRs); beta-naphthol; thiamine hydrochloride (VB1)

摘要：A three-component condensation reaction involving beta-naphthol, aldehyde, and urea in the presence of 10 mol% thiamine hydrochloride (VB1) as a catalyst is described. Aromatic aldehydes bearing different functional groups exhibited different behavior than b-naphthol and urea under similar reaction conditions. A possible mechanism to account for the reaction is proposed.