文献类型：期刊文献

英文题名：An Organocatalytic Approach to the Construction of Chiral Oxazolidinone Rings and Application in the Synthesis of Antibiotic Linezolid and Its Analogues

作者：Song, Lirong[1];Chen, Xiaobei[1];Zhang, Shilei[1];Zhang, Haoyi[1];Li, Ping[1];Luo, Guangshun[1];Liu, Wenjing[1];Duan, Wenhu[1,2];Wang, Wei[1,3]

机构：[1]E China Univ Sci & Technol, Dept Pharmaceut Sci, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Grad Sch, Shanghai 201203, Peoples R China;[3]Univ New Mexico, Dept Chem & Biol Chem, Albuquerque, NM 87131 USA

年份：2008

卷号：10

期号：23

起止页码：5489

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000261294300043)，CCR-EXPANDED(收录号:WOS:000261294300043)】；

基金：We are grateful for financial support from National Science Foundation of China (0801031005), Chinese National Programs for High Technology Research and Development (0604071005 and 0704051005), and the New Drug Basic Research Program of the Shanghai Institute of Materia Medica (07G603B005).

语种：英文

摘要：An efficient, catalytic asymmetric approach to antibacterial agent linezolid has been developed. The route features organocatalytic, highly enantioselective aldol and Beckman rearrangement reactions. The strategy has also been successfully applied for the preparation of new alpha-substituted analogues with high enantio- and diastereoselectivity.